“RE: How to Install DBD::mysql on Mac OS X 10.3 (Panther)”

I saw that the way to fix this in general is to edit line 822 of /System/Library/Perl/5.8.1/darwin-thread-multi-2level/Config.pm


As it comes from Apple:
ld='MACOSX_DEPLOYMENT_TARGET=10.3 cc'
As it should be:
ld='env MACOSX_DEPLOYMENT_TARGET=10.3 cc'

This does exactly what your perl search/replace does, except for all perl Makefiles.